PI组长：
       徐建雄  教授    

组员：
       徐维娜 张京

研究方向：
       动物氧化应激机制

主要研究领域：

主要研究动物生产过程中的氧化应激现象，聚焦氧化应激与动物生长发育和生产的关系及其机制；研发高效、环境友好的营养调控技术和产品；建立和完善健康（生态）养殖模式。主要研究领域如下：

1. 动物氧化应激机制

2. 氧化应激营养调控技术

3. 生物饲料

4. 健康养殖（生态）模式

PI研究组代表性成果：

1、主要研究项目：

(1) 国家自然科学基金项目 ROS-NLRP3信号通路研究断奶仔猪肠道炎症反应机制及雪莲果酚酸的调控作用

(2) 国家自然科学基金项目 早期断奶仔猪自由基代谢与消化道结构和功能的关系研究

(3) 国家自然科学基金项目 GPR40介导的团头鲂beta细胞胰岛素分泌及脂性凋亡的调控机制

(4) 国家自然科学基金青年基金项目 高脂胁迫对团头鲂肝脏组织载脂蛋白基因表达及甲基化分析

(5) 国家自然科学基金青年基金项 基于ROS-HMGB1信号通路研究断奶仔猪肠上皮细胞自噬机制及胞外多糖调控作用

(6) 国家重点研发计划 畜禽肠道健康与消化道微生物互作机制研究

(7) 国家重点研发计划 畜禽养殖绿色安全饲料饲养新技术研发

(8) 上海市科技兴农重点攻关项目 新型饲料添加剂研制

(9) 上海市科技兴农创新项目 菌菇菇根和菌渣生物发酵高值利用关键技术研究

(10) 国家科技支撑计划 高效安全新型饲料研制与产业化开发

2、成果专利与奖励：

       发明专利

(1) 复合益生菌发酵饲料的制备方法 ZL 201010129568.5

(2) 抗氧化保健鸡蛋的生产方法及其使用的复合抗氧化剂ZL 201110247562.2

(3) 提高雄性动物精液品质的复合抗氧化剂ZL 201010515368.3

(4) 猪用营养性抗应激生物修复组合物及其制备方法 ZL20120553201.5

(5) 纳米沸石组装体固载植酸酶复合饲料添加剂的制备方法ZL201310304269.4

(6) 一种改善黄颡鱼鱼苗食性转换期肠道功能的微生态饲料ZL 201310103740.3

(7) 一种克氏螯虾抗应激饲料及其生产方法ZL 201210034136.5

科技奖励

(1) 集约化养猪的氧化应激与营养调控技术研究与应用 2018年中国产学研合作创新成果二等奖

(2) 集约化养猪的氧化应激与营养调控技术研究与应用 2017年上海市科学技术进步二等奖

(3) 绿色水产营养调控技术体系构建及其在淡水鱼虾中的应用 2016年江苏省科学技术进步二等奖

(4) 提高母猪繁殖性能的“孕育康”微生物饲料添加剂 20011年上海市技术发明奖三等奖

(5) 食用畜产品生产中替代抗生素的生物技术研究与开发 2007年上海市科技进步奖三等奖

(6) 基于微生物技术的动物源食品安全生产体系的建立与应用 2005年上海市科技进步奖三等奖

3、代表论著：

(1) Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress Food & Nutrition Research.2019.63:3504,http://dx.doi.org/10.29219/fnr.v63.3504

(2) The Effect of Maternal Diet with Fish Oil on Oxidative Stress and Inflammatory Response in Sow and New-Born Piglets Oxidative Medicine and Cellular Longevity 2019,https://doi.org/10.1155/2019/6765803

(3) Effects of n-acetyl-cysteine supplementation in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome, and fecal microbiota in sows. J.Anim.Sci.2019.97:1757–1771

(4) ROS-induced autophagy regulates porcine trophectoderm cell apoptosis,proliferation, and differentiation. Am J Physiol Cell Physiol 2019.316:C198-C209

(5) Growth performance, digestion and metabolism to fish meal replacement by rice protein concentrate in Chinese soft-shelled turtle Pelodiscus sinensis Aquaculture 2018.492:321–326

(6) Molecular characterization of Microtubule-associated protein 1-light chain 3 B in 2018 journal of applied genetics 2018.59 345-355

(7) Reactive oxygen species mediated placental oxidative stress, mitochondrial content, and cell cycle progression through mitogen-activated protein kinases in intrauterine growth restricted pigs Reproductive Biology 2018.18 422–431

(8) Growth performance, digestion and metabolism to fish meal replacement by rice protein concentrate in Chinese soft-shelled turtle Pelodiscus sinensis. Aquaculture, 2018, 492: 321-326

(9) Different preference is modulated by the feeding stimulants supplementation in different Chinese soft-shelled turtle (Pelodiscus sinensis) basic diets. Aquaculture Nutrition, 2018, 24(1): 195-203

(10) Growth performance, innate immune responses and diseaseresistance of fingerling blunt snout bream, Megalobrama amblycephala adapted to different berberine-dietary feeding modes. Fish and Shellfish immunology, 2017,68:458-465

(11) Effects of dietary biotin on growth performance and fatty acids metabolism in blunt snout bream, Megalobrama amblycephala fed with different lipid levels diets. Aquaculture, 2017, 479:790-797

(12) Weaning Induced Hepatic Oxidative Stress, Apoptosis, and Aminotransferases through MAPK Signaling Pathways in Piglets  Oxidative Med Cell Longev, Volume 2016, Article ID 4768541, http://dx.doi.org/10.1155/2016/4768541

(13) X/XO or H2O2 induced IPEC-J2 cell as a new in vitro model for studying apoptosis in post-weaning piglets. Cytotechnology 2016，68:713–724

(14) Identification and differential expression of hepatopancreas microRNAs in red swamp crayfish fed with emodin diet. Fish and Shellfish immunology,2014,39(1):1-7

(15) Regulation of N-acetyl cysteine on gut redox status and major microbiota in weaned piglets J.Anim.Sci. 2014,92:1504-1511

(16) Gene expression profiling analysis reveals weaning-induced cell cycle arrest and apoptosis in the small intestine of pigs J.Anim.Sci. 2014,92:996-1006

(17) Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets Nutrition 2014,(30):584–589

(18) A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine，The Journal of Nutrition，2013，143（3）：274-283

(19) Effectof N-acetylcysteine on enterocyte apoptosis and intracellular signalling pathways response to oxidative stress in weaned piglet. British Journal of Nutrition, 2013.(110), 1938–1947

(20) Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs.J.Anim.Sci.2012.90:2581–2589